Cancer vaccine eliminates tumors in mice

Cancer vaccine successfully eliminates tumors in mice

Researchers at the Stanford University School of Medicine injected a cancer vaccine in 90 mice, and a lot of them were cured.

In lab tests, 87 of 90 mice were cured of lymphoma tumors.

"When we use these two agents together, we see the elimination of tumors all over the body", Ronald Levy, professor of oncology, told the Stanford Medicine News Center.

Unlike other cancer treatments already in the market and that involves a lengthy treatment process and comes with rough side effects besides being expensive, the new method is simpler. The cancer did recur in three of the animals, but the tumors later regressed after another round of immune treatment. This activated the T cells in the mice, the cells responsible for determining how the immune system responds to foreign substances and illnesses.

To eliminate the tumors, researchers used an immunotherapy approach by activating T cells in cancerous tumors. One of the agents used in this vaccination is already approved to be used on humans, while the other is still being tested in clinical trials.

The new experiment for cancer treatment targeting cancer cells in laboratory mice involved a combination of two immune boosters that were directly injected into solid mouse tumours.

Trials using human guinea pigs are taking part to test the vaccine that could cure the disease - even after it enters the bloodstream. The study was also successful in mice that had breast, colon and melanoma tumors. "We're attacking specific targets without having to identify exactly what proteins the T cells are recognsing".


The treatment takes only one-millionth of a gram injected into the tumorous area which reactivates cancer-specific T-cells in the human body.

Treating the first tumour that arose often prevented the occurrence of future tumours and significantly increased the animals' lifespan.

Researchers at Stanford University have discovered a possible "vaccine" to treat cancer.

"Our approach uses a one-time application of very small amounts of two agents to stimulate the immune cells only within the tumour itself".

The next step for the scientists is a small trial with 15 people who have been diagnosed with low-grade lymphoma.

Levy is hopeful this treatment will be successful on multiple types of tumors.

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